Functional genomics of human pre-implantation development
نویسندگان
چکیده
منابع مشابه
Functional genomics of human pre-implantation development.
Early mammalian embryogenesis is currently the focus of intense interest because of the potential of inner cell mass-derived embryonic stem cell lines in new therapeutic strategies. As such, creating molecular profiles of gene expression during pre-implantation development will provide a framework for understanding the biological properties of these cells and also establish a tool set for subse...
متن کاملHuman pre-implantation embryo development.
Understanding human pre-implantation development has important implications for assisted reproductive technology (ART) and for human embryonic stem cell (hESC)-based therapies. Owing to limited resources, the cellular and molecular mechanisms governing this early stage of human development are poorly understood. Nonetheless, recent advances in non-invasive imaging techniques and molecular and g...
متن کاملTranscriptome Profiling of Human Pre-Implantation Development
BACKGROUND Preimplantation development is a crucial step in early human development. However, the molecular basis of human preimplantation development is not well known. METHODOLOGY By applying microarray on 397 human oocytes and embryos at six developmental stages, we studied the transcription dynamics during human preimplantation development. PRINCIPAL FINDINGS We found that the preimplan...
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Background: Hyaluronan (HA) is a structural component of extracellular matrix synthesised by HA synthases HAS1-3, which produce HA of different molecular sizes with distinct biological functions associated with reproductive processes. Hyaluronidase (HYAL) cleaves the HA into biologically active small fragments which are known to regulate cell proliferation through CD44 receptor signaling. HA is...
متن کاملEffect of diabetes mellitus on quality and quantity pregnant rat in Pre-implantation embryo development
Introduction: Women with poorly controlled insulin-dependent diabetes mellitus (IDDM) have a much higher incidence of early pregnancy complications, these include spontaneous miscarriages, early growth delay, and congenital malformations. Most of the investigations have been devoted to the early post implantation and organogenesis period of pregnancy. In this research we studied the hyperglycem...
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ژورنال
عنوان ژورنال: Briefings in Functional Genomics and Proteomics
سال: 2007
ISSN: 1473-9550,1477-4062
DOI: 10.1093/bfgp/elm012